Table 1.
The outcomes and number of patients with affective disorders and healthy control along with the side of standardized mean difference (SMD) and the 95% confidence intervals with respect to zero SMD.
| Outcome profiles | n studies | Side of 95% confidence intervals |
Patient Cases |
Control Cases |
Total number of participants | |||
|---|---|---|---|---|---|---|---|---|
| <0 | Overlap 0 and SMD <0 | Overlap 0 and SMD >0 | >0 | |||||
| TRP | 106 | 48 | 48 | 8 | 2 | 5753 | 5288 | 11041 |
| TRP/CAAs | 18 | 7 | 11 | 0 | 0 | 423 | 607 | 1030 |
| CAAs | 14 | 1 | 6 | 4 | 3 | 330 | 503 | 833 |
| KYN | 67 | 19 | 30 | 15 | 3 | 4813 | 4356 | 9169 |
| KYN/TRP | 68 | 5 | 15 | 42 | 6 | 6007 | 5437 | 11444 |
| (KYN+3HK+3HA + XA + QA + PA) | 82 | 22 | 35 | 18 | 7 | 5392 | 4853 | 10245 |
| KA/KYN | 70 | 5 | 36 | 21 | 8 | 4987 | 4322 | 9309 |
| KA | 55 | 16 | 25 | 10 | 4 | 3905 | 3464 | 7369 |
| 3HK | 26 | 4 | 10 | 11 | 1 | 1364 | 1244 | 2608 |
TRP: Tryptophan, KYN: Kynurenine, KA: Kynurenic acid, 3HK: 3-Hydroxykynurenine, 3HA: 3-Hydroxyanthranilic acid, XA: Xanthurenic acid, QA: Quinolinic acid, PA: Picolinic acid, AA: Anthranilic acid, SMD: Standardized Mean Difference, CAAs: Competing amino acids (Valine + Phenylalanine + Tyrosine + Leucine + Isoleucine).