Table 3.
Results on publication bias.
| Outcome feature sets | Fail safe n | Z Kendall's τ | p | Egger's t-test (df) | p | Missing studies (side) | After Adjusting |
|---|---|---|---|---|---|---|---|
| TRP (Overall) | −20.06 | 2.42 | 0.007 | 5.62(104) | <0.0001 | 22(Right) | −0.324(-0.427;-0.222) |
| TRP/CAAs (Overall) | −7.56 | 1.89 | 0.029 | 2.66(16) | 0.008 | 6 (Right) | −0.344(-0.568; −0.120) |
| CAAs (Overall) | −0.992 | 0.43 | 0.330 | 0.407(12) | 0.345 | 1(Right) | −0.008(-0.283; 0.265) |
| KYN (Overall) | −8.03 | 0.270 | 0.393 | 0.425(65) | 0.336 | 11(Right) | −0.108(-0.199;-0.016) |
| KYN (CNS) | 1.99 | <0.0001 | 0.500 | 1.10(3) | 0.174 | 0 | – |
| KYN (Plasma) | −8.82 | 0.013 | 0.494 | 0.892(35) | 0.188 | 0 | – |
| KYN (Serum) | −2.18 | 0.925 | 0.177 | 0.659(24) | 0.257 | 3(Right) | 0.067(-0.195; 0.061) |
| KYN/TRP (Overall) | 1.35 | 0.820 | 0.205 | 4.02(66) | 0.00008 | 20(Left) | −0.074(-0.160; 0.010) |
| (KYN+3HK+3HA + XA + QA + PA) (Overall) |
−5.75 | 0.176 | 0.430 | 0.007(80) | 0.497 | 21(Right) | 0.056(-0.048; 0.161) |
| KA/KYN (Overall) | 0.965 | 0.192 | 0.423 | 0.219(68) | 0.413 | 18(Right) | 0.149(0.065; 0.233) |
| KA (Overall) | −8.66 | 0.392 | 0.347 | 0.304(53) | 0.381 | 14(Right) | −0.074(-0.195; 0.047) |
| KA (CNS) | 1.94 | 0.312 | 0.377 | 0.433(7) | 0.338 | 2(Right) | 0.280(-0.001; 0.563) |
| KA (Plasma) | −9.08 | 1.10 | 0.133 | 1.47(21) | 0.077 | 0 | – |
| KA (Serum) | −5.52 | 0.422 | 0.336 | 1.43(21) | 0.082 | 6(Right) | −0.123(-0.284; 0.037) |
| 3HK (Overall) | −0.887 | 0.837 | 0.201 | 0.958(24) | 0.173 | 1(Right) | 0.010(-0.150; 0.181) |
TRP: Tryptophan, KYN: Kynurenine, KA: Kynurenic acid, 3HK: 3-Hydroxykynurenine, 3HA: 3-Hydroxyanthranilic acid, XA: Xanthurenic acid, QA: Quinolinic acid, PA: Picolinic acid, AA: Anthranilic acid, CAAs: Competing amino acids (Valine + Phenylalanine + Tyrosine + Leucine + Isoleucine).