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. 2022 Oct 20;13:997806. doi: 10.3389/fimmu.2022.997806

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Copyright © 2022 Mele, Pessino, Trisolini, Luchena, Benazzo, Morbini, Mantovani, Oliviero, Mondelli and Varchetta

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Frequency of FcϵRIγ negative CD56⁺/CD57⁺ adaptive NK cells in PBMC from control subjects (CTRL PB), and from HNSCC patients (HNSCC-PB) as well as matched tumor-infiltrating lymphocytes (TIL) and surrounding non-tumor-infiltrating lymphocytes (NIL). Percentage of NK cells expressing (B) CD69, (C) PD-1 (D) GITR and (E) CXCR6. (F) Frequency of PD-1+TIGIT+ NK cells. (G) Representative concatenated flow cytometry plots showing the percentage of expression of the indicated phenotypic markers on CD3^-CD56⁺ NK cells. The Mann–Whitney U test was used to compare CTRL and HNSCC subjects. Paired data were analyzed by the Wilcoxon signed rank test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.