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. 2022 Oct 20;13:997806. doi: 10.3389/fimmu.2022.997806

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Copyright © 2022 Mele, Pessino, Trisolini, Luchena, Benazzo, Morbini, Mantovani, Oliviero, Mondelli and Varchetta

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) IFNγ production and (B) degranulation ability by IL12+15+18 pre-activated NK cells following stimulation with SW480 with or without Cetuximab. Paired data were analyzed by the Wilcoxon signed rank test. The non-parametric Kruskal-Wallis followed by Dunn’s multiple test were used to compare different datasets. *p < 0.05, **p < 0.01, ***p < 0.001. (C) IFNγ and (D) CD107a expression negatively correlated with TIGIT expression on peripheral NK cells. (E) Intratumoral IFNγ expression negatively correlate with TIGIT expression on tumor infiltrating NK cells. The Pearson test was used to examine correlations.