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. 2022 Oct 20;13:997806. doi: 10.3389/fimmu.2022.997806

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Copyright © 2022 Mele, Pessino, Trisolini, Luchena, Benazzo, Morbini, Mantovani, Oliviero, Mondelli and Varchetta

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of (A, B) the GITR costimulatory molecule and (C, D) of the TIGIT checkpoint molecule on CD4+ and CD8+ T cells. The Mann–Whitney U test was used to compare CTRL and HNSCC subjects. Paired data were analyzed by the Wilcoxon signed rank test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. (E) Representative concatenated flow cytometry plots showing the percentage of GITR-expressing CD4+ and CD8+ T cells. (F) Representative concatenated flow cytometry plots showing the percentage of TIGIT expression on CD4+ and CD8+ T cells.