Figure 3.

Structural lesion network mapping. White matter seeds were derived from the LBMs and submitted as seed regions-of-interest in a deterministic fiber tractography analysis. Each LBM was associated with three or more seeds. The results were calculated for each seed and then submitted to a PCA. The seeds associated with the map of the Boston Naming Test identified the white matter tracts between the left frontal, parietal, and temporal cortices as critical for expressive language and naming. The seeds associated with the map of the Token Test identified tracts between the left frontal, parietal, and temporal cortices as being critical for receptive language. The seeds associated with the map of the Rey Auditory-Verbal Learning Test Delayed Recall identified tracts within the left inferior temporal cortex and the left frontal lobe as being critical for anterograde verbal memory. The seeds associated with the map of the Fugl-Meyer Test identified tracts descending from the bilateral primary motor cortices as being critical for upper extremity motor function. Colour scales for the principal component maps indicate the corresponding principal component score at each voxel. For each map, we also depict the amount of variance that can be predicted (R²) in the WU cohort's corresponding behavioural test's latent growth curve intercept. We also present the average variance explained in each WU cohort test when predicted from the non-target functional LNM maps (i.e. the principal component structural LNM maps from the other behavioural domains). Error bars represent standard error. ARAT = Action Research Arm Test; BNT = Boston Naming Test; CIM = Complex Ideational Material Test; HVLT = Delayed Recall from the Hopkins Verbal Learning Test; Int = Intercept for the WU Cohort Latent Growth Curve Model; Param = Type of WU Cohort Latent Growth Curve Parameter; Slp = Slope for the WU Cohort Latent Growth Curve Model.