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. 2021 Dec 17;145(2):744–753. doi: 10.1093/brain/awab442

Figure 2.

Figure 2

Distinctive regional patterns of neuronal synchrony deficits in Alzheimer’s disease patients with and without epileptiform activity. (A–F) Statistical comparisons of imaginary coherence between groups. Within the alpha band, AD-EPI− and AD-EPI+ showed significantly reduced imaginary coherence compared to controls, over bilateral occipital cortices, with more extensive regional involvement in AD-EPI+ (A and B). Pairwise comparison showed AD-EPI+ with significantly lower alpha imaginary coherence than AD-EPI− (C). AD-EPI− and AD-EPI+ showed significantly increased delta–theta imaginary coherence compared to controls, over bilateral frontal and parietal cortices, with more extensive involvement in AD-EPI+ (D and E) and pairwise comparison showed AD-EPI+ with significantly higher delta–theta imaginary coherence than AD-EPI− (F). Each brain rendering depicts the t-maps from voxelwise comparison of global imaginary coherence between groups. The colour maps are thresholded with a cluster correction of 30 voxels (P < 0.01) and at 5% FDR. (C and F) depict least squares (LS)-means and 95% confidence-limits (n = 30, AD-EPI+; n = 20 AD-EPI−; n = 35 age-matched controls). Alzheimer’s disease = Alzheimer’s disease; AD-EPI− = Alzheimer’s disease patients without epileptiform activity; AD-EPI+ = Alzheimer’s disease patients with epileptiform activity; IC = imaginary coherence.