Table 2.

Characteristics of Candidate Single-nucleotide Polymorphisms (n = 151).

Gene	SNP ID	Allele	Change	Poly/HT/WT	HWE	Role
APOE	rs429358	C/T	Cys156Arg	3/30/118	0.91	Cognitive function (Koleck et al., 2014; Lengacher, Reich, et al., 2015a)
BDNF	rs6265	T/C	Val66Met	5/44/102	1.00	Cognitive impairment (Ng et al., 2016)
HTR2A	rs6313	A/G	Ser34SER	26/78/47	0.90	Cognitive function (Kurita et al., 2016)
HTR2A	rs6314	A/G	His452Asn	0/28/123	0.49
ANKK1	rs1800497	A/G	Glu713Lys	7/45/99	0.91	Cognitive function (Lengacher, Reich, et al., 2015)
AK091365	rs1487441	G/A	none	31/81/39	0.80	Cognitive function (Davies et al., 2016; Rietveld et al., 2014)
AKAP6	rs17522122	G/T	3’UTR	39/70/42	0.82	Cognitive function (Andrews et al., 2017; Davies et al., 2015, 2016)
TOMM40	rs10119	G/A	3’UTR	8/60/83	0.89	Cognitive function (Davies et al., 2015)
BCL11A	rs7581162	T/A	Intron	28/82/41	0.71	Cognitive function (Le Hellard et al., 2017)
APBA1	rs3897757	A/G	intron	33/73/45	0.97	Cognitive function (Davies et al., 2016; Sloan et al., 2010)
CYP2D6	rs5758605	A/G	upstream	31/70/50	0.88	Cognitive function, depression (Cacabelos, 2007)
MTHER	rs1801133	C/T	Ala222Asp	19/70/62	1.00	Cognitive function (Jiang et al., 2016; Schiepers et al., 2012) Heart defect (H. L. Yang et al., 2018)
Intergenic	rs28714259	G/A	none	2/24/125	0.91	Heart failure (Linschoten et al., 2018; Schneider et al., 2017)
CHD13	rs8055236	G/A	intron	4/53/94	0.72	Heart disease (Angelakopoulou et al., 2012; Bressler et al., 2010)
CXCL12	rs1746048	C/T	none	2/30/119	1.00	Cardiovascular health (Ansari et al., 2019; Spiller et al., 2020)
CDKN2B	rs1333049	G/A	none	38/75/38	1.00	Coronary artery disease (Hu et al., 2019; Trenkwalder et al., 2019)