TABLE 3.
Association between coffee consumption and endometrial cancer risk1
| Coffee exposure | Controls, n | Cases, n | OR2 (95% CI) | P value | OR3 (95% CI) | P value |
|---|---|---|---|---|---|---|
| Coffee consumption | 25,982 | 11,109 | ||||
| No | 3895 | 1939 | 1.00 (Ref.) | 0.016 | 1.00 (Ref.) | 0.0028 |
| Yes | 22,087 | 9170 | 0.92 (0.85, 0.98) | 0.87 (0.79, 0.95) | ||
| Coffee cups per day | 25,088 | 10,734 | ||||
| No coffee | 3895 | 1939 | 1.00 (Ref.) | 1.76 × 10−5 | 1.00 (Ref.) | 9.21 × 10−5 |
| 1 cup/d | 8711 | 3821 | 0.96 (0.88, 1.03) | 0.90 (0.82, 1.00) | ||
| 2–3 cups/d | 8703 | 3678 | 0.93 (0.85, 1.00) | 0.86 (0.78, 0.95) | ||
| >4 cups/d | 3779 | 1296 | 0.78 (0.70, 0.86) | 0.76 (0.66, 0.87) |
1
Reported sample sizes correspond to model 1 (adjusting for age and race only). For the multiadjusted model 2, the sample size for the complete-case analysis was 21,389 controls and 8873 cases.
2
ORs adjusted for age and race.
3
ORs adjusted for age, race, BMI, pack-years of smoking, energy intake, study design, and study site.