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. 2022 Oct 20;9:990007. doi: 10.3389/fcvm.2022.990007

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Copyright © 2022 Liu, Liu, Wei and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The human IL-33 gene. The molecular weight of human IL-33 is about 18 kDa, and its gene span is > 42 kb. The main promoter of human IL-33 mRNA is upstream of the untranslated exon. The human IL-33-encoding gene contains eight exons. Exon 1b may replace the promoter. There are CAD related SNPs in promoter and intron 1 regions. Previous studies have reported the absence of splicing variants on exons 3/4/5/8, which may lead to the production of spliced IL-33 proteins.