Table 3.
Effect of PSQI measures on CSF biomarkers at baseline
| Variables | log(CSF Aβ42) | log(CSF P-tau) | log(CSF t-tau) | |||
|---|---|---|---|---|---|---|
| β Coefficient (95% CI) | P-value | β Coefficient (95% CI) | P-value | β Coefficient (95% CI) | P-value | |
| Total PSQI score | −0.003 (−0.012 0.006) | 0.809 | 0.002 (−0.005 0.008) | 0.609 | 0.003 (−0.003 0.008) | 0.344 |
| Dichotomized PSQI score (ref. Total PSQI ≤5) | −0.013 (−0.064 0.039) | 0.63 | 0.039 (−0.002 0.081) | 0.062 | 0.044 (0.007 0.08) | 0.018 |
| Sleep latency (ref. ≤ 15 min) | ||||||
| 16–30 min | −0.039 (−0.094 0.015) | 0.153 | 0.007 (−0.038 0.053) | 0.759 | 0.001 (−0.039 0.041) | 0.946 |
| 31–60 min | 0.033 (−0.041 0.107) | 0.382 | −0.007 (−0.068 0.054) | 0.824 | −0.008 (−0.062 0.046) | 0.767 |
| >60 min | 0.058 (−0.05 0.165) | 0.29 | −0.02 (−0.108 0.069) | 0.665 | −0.014 (−0.092 0.064) | 0.728 |
| Sleep duration (ref. > 7 h) | ||||||
| 6–7 h | −0.034 (−0.089 0.022) | 0.232 | 0.069 (0.023 0.115) | 0.003 | 0.057 (0.016 0.097) | 0.006 |
| 5–6 h | −0.04 (−0.125 0.045) | 0.356 | 0.019 (−0.052 0.09) | 0.597 | 0.036 (−0.026 0.098) | 0.259 |
| <5 h | 0.097 (−0.076 0.27) | 0.272 | −0.01 (−0.151 0.131) | 0.89 | 0.014 (−0.11 0.138) | 0.824 |
| Sleep efficiency (ref. > 85%) | ||||||
| 75–84% | −0.036 (−0.093 0.021) | 0.212 | 0.015 (−0.033 0.062) | 0.545 | 0.015 (−0.027 0.057) | 0.481 |
| 65–74% | −0.039 (−0.118 0.04) | 0.335 | 0.029 (−0.036 0.094) | 0.385 | 0.024 (−0.034 0.081) | 0.418 |
| <65% | −0.002 (−0.086 0.082) | 0.961 | 0.039 (−0.03 0.108) | 0.267 | 0.046 (−0.015 0.107) | 0.138 |
| Sleep disturbance (ref. 0)a | ||||||
| 1–9 | −0.125 (−0.219 −0.031) | 0.009 | 0.016 (−0.063 0.094) | 0.695 | 0.034 (−0.035 0.104) | 0.334 |
| >9 | −0.121 (−0.23 -0.012) | 0.03 | 0.016 (−0.074 0.107) | 0.722 | 0.028 (−0.052 0.108) | 0.49 |
| Daytime dysfunction (ref. 0)b | ||||||
| 1–2 | −0.037 (−0.09 0.016) | 0.173 | 0.018 (−0.025 0.06) | 0.411 | 0.014 (−0.023 0.052) | 0.448 |
| >2 | −0.032 (−0.15 0.087) | 0.6 | −0.085 (−0.182 0.011) | 0.084 | −0.06 (−0.145 0.025) | 0.165 |
ref.: Level of reference. aCategories corresponding to scores of ‘10–18’ and ‘19–27’ have been collapsed due to <20 observations in one category. bCategories corresponding to scores of ‘3–4’ and ‘5–6’ have been collapsed due to <20 observations in one category. All models with log(CSF Aβ42) as an outcome are adjusted by age, sex, site of data collection, APOE-ɛ4 carriership, anxiety (State-Trait Anxiety Inventory) and log(CSF p-tau) levels. All models with log(p-tau) and log(CSF t-tau) levels as outcomes are adjusted by age, sex, site of data collection, APOE-ɛ4 carriership, body mass index, physical activity and log(CSF Aβ42) levels.