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. 2022 Sep 15;9(31):2201888. doi: 10.1002/advs.202201888

Figure 4.

Figure 4

A) Proximity of tumor cells to the microvascular network. Data points represent the fraction of tumor cells that are a specified distance from the microvascular network in a single hydrogel. Data analyzed using one‐way ANOVA with Scheffe's post‐hoc or Kruskal‐Wallis test with Dunn's post‐hoc; *p < 0.05, **p < 0.01, ***p < 0.001; N = 17–18 hydrogels. B) Representative images of tumor‐vascular cocultures with SOX2 staining. Scale bar = 200 µm. C) Quantification of the fraction of RFP‐expressing tumor cells that express SOX2. Data analyzed with one‐way ANOVA with Tukey's post‐hoc; *p < 0.05, **p < 0.01; N = 6 hydrogels. D) Comparing the proximity of SOX2‐ versus SOX2+ GBM6 cells to the microvascular network. Data points represent the fraction of tumor cells that are a specified distance from the microvascular network in a single hydrogel. Data analyzed using paired‐sample t‐tests; *p < 0.05, **p < 0.01, ***p < 0.001; N = 6 hydrogels.