Table 1.
Echocardiographic parameters in db/db mice
| db/m (n = 6) | db/db | |||
|---|---|---|---|---|
| Vehicle (n = 6) | Sch B‐20 (n = 6) | Sch B‐40 (n = 6) | ||
| EF % a) | 84.24 ± 1.38 | 72.33 ± 1.73*** | 80.24 ± 1.95## | 78.89 ± 0.98# |
| FS % | 47.05 ± 1.68 | 35.8 ± 1.3*** | 42.99 ± 1.93# | 41.7 ± 0.85# |
| LVIDd (mm) | 2.32 ± 0.07 | 2.85 ± 0.12** | 2.75 ± 0.13 | 2.58 ± 0.11 |
| LVIDs (mm) | 1.35 ± 0.06 | 1.83 ± 0.1** | 1.57 ± 0.09 | 1.53 ± 0.09 |
| LVFWd (mm) | 0.62 ± 0.02 | 0.72 ± 0.02** | 0.69 ± 0.01 | 0.67 ± 0.02 |
| LVFWs (mm) | 0.92 ± 0.02 | 0.93 ± 0.02 | 0.85 ± 0.04 | 0.87 ± 0.02 |
| LVPWd (mm) | 0.6 ± 0.02 | 0.73 ± 0.02** | 0.7 ± 0.02 | 0.68 ± 0.02 |
| LVPWs (mm) | 0.82 ± 0.03 | 0.9 ± 0.02 | 0.87 ± 0.02 | 0.9 ± 0.02 |
| IVSd (mm) | 0.62 ± 0.02 | 0.75 ± 0.02** | 0.7 ± 0.02 | 0.7 ± 0.02 |
| E wave (m s−1) | 0.79 ± 0.08 | 0.6 ± 0.03* | 0.61 ± 0.04 | 0.63 ± 0.03 |
| IRT (ms) | 18 ± 0.62 | 25 ± 1.56*** | 19.33 ± 0.73## | 22 ± 0.78 |
| HW/TL | 8.29 ± 0.42 | 8.74 ± 0.3 | 7.76 ± 0.27 | 8.44 ± 0.3 |
a)
EF = ejection fraction; FS = fractional shortening; LVIDd/s = diastole/systole left ventricle internal dimension; LVFWd/s = LV free wall thickness at diastole/systole; LVPWd/s = LV posterior wall thickness at diastole/systole; IVSd = diastole interventricular septal thickness; IRT = isovolumic relaxation time; HW/TL, heart weight/tibia length. Data presented as mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001 compared to db/m; #p < 0.05, ##p < 0.01 compared to db/db.