Table 2.
Echocardiographic parameters in streptozotocin‐induced diabetic model
| Ctrl (n = 6) | Sch B‐40 (n = 6) | T1DM | |||
|---|---|---|---|---|---|
| Vehicle (n = 6) | SchB‐20 (n = 6) | Sch B‐40 (n = 6) | |||
| EF % a) | 81.9 ± 0.869 | 80.3 ± 1.269 | 73.7 ± 0.876*** | 79.0 ± 0.705### | 79.2 ± 0.767### |
| FS % | 43.1 ± 1.623 | 42.1 ± 1.632 | 35.1 ± 0.693*** | 40.3 ± 0.688## | 40.2 ± 0.896## |
| LVIDd (mm) | 2.20 ± 0.041 | 2.16 ± 0.040 | 2.35 ± 0.056* | 2.22 ± 0.049 | 2.16 ± 0.042# |
| LVIDs (mm) | 1.26 ± 0.042 | 1.30 ± 0.037 | 1.47 ± 0.064** | 1.35 ± 0.022 | 1.30 ± 0.026# |
| LVFWd (mm) | 0.73 ± 0.004 | 0.72 ± 0.019 | 0.77 ± 0.005** | 0.75 ± 0.009 | 0.73 ± 0.005# |
| LVFWs (mm) | 0.86 ± 0.002 | 0.86 ± 0.002 | 0.84 ± 0.009 | 0.84 ± 0.011 | 0.84 ± 0.011 |
| LVPWd (mm) | 0.71 ± 0.004 | 0.71 ± 0.012 | 0.75 ± 0.008** | 0.72 ± 0.004# | 0.72 ± 0.008# |
| LVPWs (mm) | 0.87 ± 0.008 | 0.87 ± 0.006 | 0.89 ± 0.004* | 0.89 ± 0.003 | 0.86 ± 0.008# |
| IVSd (mm) | 0.68 ± 0.002 | 0.69 ± 0.009 | 0.74 ± 0.011*** | 0.71 ± 0.006# | 0.70 ± 0.007# |
| IVSs (mm) | 0.86 ± 0.009 | 0.86 ± 0.005 | 0.87 ± 0.008 | 0.86 ± 0.008 | 0.84 ± 0.009 |
| Heart weight, mg | 133.5 ± 4.60 | 134.5 ± 5.81 | 104.1 ± 4.93*** | 107.1 ± 5.53# | 103.6 ± 6.78## |
| HW/BW, mg g−1 | 4.58 ± 0.08 | 4.72 ± 0.1 | 5.32 ± 0.07*** | 4.90 ± 0.17# | 4.85 ± 0.11# |
a)
EF = ejection fraction; FS = fractional shortening; LVIDd/s = diastole/systole left ventricle internal dimension; LVFWd/s = LV free wall thickness at diastole/systole; LVPWd/s = LV posterior wall thickness at diastole/systole; IVSd/s = diastole/systole interventricular septal thickness; IRT = isovolumic relaxation time; HW/BW = heart weight/body weight. Data presented as mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001 compared to Ctrl; #p < 0.05, ##p < 0.01, ###p < 0.001 compared to T1DM.