Table 1. Demographic and Clinical Characteristics of the Cohort According to the Type of Taxanes.
| Characteristic | Patients, No. (%) | P value | |||
|---|---|---|---|---|---|
| Nab-paclitaxel (n = 295) | Paclitaxel (n = 514) | Docetaxel (n = 425) | Overall (N = 1234) | ||
| Age, mean (SD), y | 51.9 (11.1) | 50.6 (10.5) | 50.7 (9.6) | 50.9 (10.4) | .20 |
| Ethnicity | |||||
| Han | 276 (93.6) | 484 (94.2) | 395 (92.9) | 1155 (93.6) | .75 |
| Other minority groupa | 19 (6.4) | 30 (5.8) | 30 (7.1) | 79 (6.4) | |
| Geographic region | |||||
| Central China | 13 (4.4) | 30 (5.8) | 12 (2.8) | 55 (4.5) | <.001 |
| East China | 24 (8.1) | 62 (12.1) | 34 (8.0) | 120 (9.7) | |
| North China | 121 (41.0) | 327 (63.6) | 203 (47.8) | 651 (52.8) | |
| Northeast China | 122 (41.4) | 73 (14.2) | 161 (37.9) | 356 (28.8) | |
| Northwest China | 9 (3.1) | 7 (1.4) | 8 (1.9) | 24 (1.9) | |
| South China | 5 (1.7) | 6 (1.2) | 4 (0.9) | 15 (1.2) | |
| Southwest China | 1 (0.3) | 9 (1.7) | 3 (0.7) | 13 (1.1) | |
| BMI, mean (SD) | 24.1 (3.2) | 23.8 (3.4) | 24.0 (3.6) | 23.9 (3.4) | .59 |
| Diabetes | |||||
| No | 262 (88.8) | 487 (94.7) | 406 (95.5) | 1155 (93.6) | <.001 |
| Yes | 33 (11.2) | 27 (5.3) | 19 (4.5) | 79 (6.4) | |
| History of peripheral neuropathy | |||||
| No | 286 (96.9) | 510 (99.2) | 413 (97.2) | 1209 (98.0) | .03 |
| Yes | 9 (3.1) | 4 (0.8) | 12 (2.8) | 25 (2.0) | |
| Tumor Ki-67, % | |||||
| <20 | 26 (8.8) | 100 (19.5) | 75 (17.7) | 201 (16.3) | <.001 |
| ≥20 | 176 (59.7) | 412 (80.1) | 231 (54.3) | 819 (66.4) | |
| Missing | 93 (31.5) | 2 (0.4) | 119 (28.0) | 214 (17.3) | |
| Treatment stage | |||||
| Adjuvant | 112 (38.0) | 400 (77.8) | 328 (77.2) | 840 (68.1) | <.001 |
| Neoadjuvant | 46 (15.6) | 84 (16.3) | 57 (13.4) | 187 (15.1) | |
| Palliative | 137 (46.4) | 30 (5.8) | 40 (9.4) | 207 (16.8) | |
| Chemotherapy regimens | |||||
| Combinationsb | 172 (58.3) | 249 (48.4) | 325 (76.5) | 746 (60.5) | <.001 |
| Monotherapy | 123 (41.7) | 265 (51.6) | 100 (23.5) | 488 (39.5) | |
Abbreviation: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared).
a
Including 12 ethnic minority groups: Bai, Hui, Kazakh, Korean, Manchu, Mongolian, Russian, Tibetan, Tujia, Xibo, Yi, and Zhuang.
b
Taxanes in combination with other chemotherapeutic drugs.