Table 2.
Surgical and other perioperative characteristics of participants in modified intention-to-treat population. Values are numbers (percentages) unless stated otherwise
| Characteristics | Oral prophylaxis group (n=463) | Placebo group (n=463) |
|---|---|---|
| Mean (SD) time from intervention dose to skin incision (hours) | 13.0 (1.3) | 13.1 (1.2) |
| Mean (SD) time from intravenous antimicrobial prophylaxis to skin incision (minutes)* | 36.8 (22.0) | 37.7 (24.2) |
| Type of surgery: | ||
| Colectomy | 301/463 (65) | 296/463 (64) |
| Right hemicolectomy | 121/301 (40) | 110/296 (37) |
| Left hemicolectomy | 164/301 (54) | 169/296 (57) |
| Transverse colectomy | 28/301 (9) | 23/296 (8) |
| Total colectomy | 8/301 (3) | 12/296 (4) |
| Rectal resection | 162/463 (35) | 167/463 (36) |
| Surgical method: | ||
| Open | 60 (13) | 57 (12) |
| Laparoscopic assisted | 337 (73) | 344 (74) |
| Laparoscopy converted to open | 66 (14) | 62 (14) |
| Type of anastomosis: | ||
| Stapled | 326/437 (75) | 331/430 (77) |
| Handsewn | 111/437 (25) | 99/430 (23) |
| Ileostomy or colostomy performed | 154 (33) | 153 (33) |
| Abdominal surgical drain used | 200 (43) | 192 (41) |
| Median (IQR) duration of surgery (minutes)† | 211 (160-280) | 201 (159-270) |
| Median (IQR) volume of intravenous fluid (mL): | ||
| Crystalloid | 2000 (1500-2500) | 2000 (1500-2500) |
| Colloid | 500 (500-1000) | 500 (500-1000) |
| Median (IQR) infusion rate (mL/kg/h) | 7.6 (6.0-10.3) | 8.0 (6.0-11.0) |
| Cardiac output monitoring used | 94/463 (20) | 112/463 (24) |
| Median (IQR) FiO2 (%): | ||
| Start of surgery | 44 (40-50) | 45 (40-50) |
| End of surgery | 45 (40-51) | 45 (39-51) |
| Mean (SD) core temperature at end of surgery (°C) | 36 (1) | 36 (1) |
| Received dexamethasone | 314 (68) | 320 (69) |
| Received intravenous lidocaine | 351 (76) | 330 (71) |
| Median (IQR) intraoperative blood loss (mL) | 150 (100-300) | 150 (100-300) |
| Red blood cell transfusion during surgery | 17 (4) | 14 (3) |
| Postoperative lidocaine used | 150 (32) | 133 (29) |
| Postoperative epidural analgesia used | 57 (12) | 60 (13) |
| Planned postoperative care in HDU or ICU | 117 (25) | 110 (24) |
FiO2=fraction of inspired oxygen; HDU=high dependency unit; ICU=intensive care unit; IQR=interquartile range; SD=standard deviation.
Percentages may not total 100 because of rounding.
*
Data were missing for 25 patients in the oral prophylaxis group and 20 patients in the placebo group.
†
Data were missing for three patients in the placebo group.