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. 2022 Oct 24;2(6):565–585. doi: 10.1021/acsbiomedchemau.2c00039

Figure 8.

Figure 8

Plots of the distribution of the total number of interactions (contacts) in each trajectory framework of the protein–ligand complexes of the two TP nucleotide analogues, forodesine-TP and riboprine-TP, and the two reference TP nucleotide analogue drugs, GS-443902 and NHC-TP, respectively, with: (A) SARS-CoV-2 RdRp “nsp12” enzyme cocrystallized with its protein cofactors nsp7 and nsp8 (PDB ID: 7BV2). (B) SARS-CoV-2 ExoN “nsp14” enzyme cocrystallized with its protein cofactor nsp10 (PDB ID: 7MC6).