Table 3. WADA Classification, Sequence, and HRMS-Related Characteristics of the Main Small Peptides Used in Doping.
| Compound | WADA list | Sequence | Charge state/target ion (confirming ion) [m/z] |
|---|---|---|---|
| alarelin | S2 | pGlua-HWSYdALRP-NH(Et) | 2+/584.3065 (584.8080) |
| alexamorelin | S2 | AH-dMrpa-AWdFK-NH2 | 2+/479.7560 (480.2574) |
| buserelin | S2 | pGlua-HWSY-dStBu-LRP-NH(Et) | 2+/620.3353 (620.8367) |
| deslorelin | S2 | pGlua-HWSYdWLRP-NH(Et) | 2+/641.8276 (642.3291) |
| desmopressin | S5 | Mpaa-YFQNCPdRG-NH2 (disulfide Bridge Mpa1-Cys6) | 1+/1069.4342 (1070.4370) |
| felypressin | S5 | CFFQNCPKG-NH2 (disulfide Bridge Cys1-Cys6) | 2+/520.7257 (521.2271) |
| fertirelin | S2 | pGlua-HWSYGLRP-NH(Et) | 2+/577.2987 (577.8001) |
| GHRP-1 | S2 | AH-2Nala-AWdFK-NH2 | 2+/478.2505 (478.7520) |
| GHRP-1 (3–6)b | S2 | dNala-AWdF-OH | 1+/620.2883 (621.2913) |
| GHRP-2 | S2 | dA-dNala-AWdFK-NH2 | 2+/409.7210 (410.7240) |
| GHRP-2 (1–3)b | S2 | dA-dNala-A-OH | 1+/358.1761 (359.1792) |
| GHRP-3 | S2 | Aiba-dWdPdIR-NH2 | 1+/655.4038 (656.4067) |
| GHRP-4 | S2 | dWAWdF-NH2 | 1+/608.2980 (609.3010) |
| GHRP-5 | S2 | YdWAWdF-NH2 | 1/+771.3613 (772.3643) |
| GHRP-6 | S2 | HdWAWdFK-NH2 | 1/+437.2296 (437.7312) |
| GHRP-6 (2–5)b | S2 | dWAWdF-OH | 1/+609.2820 (610.2850) |
| goserelin | S2 | pGlua-HWSY-dStBua-LRP-AzaGlya-NH2 | 2+/635.3280 (635.8294) |
| hexarelin | S2 | H-dMrpa-AWdFK-NH2 | 2+/444.2374 (444.7388) |
| hexarelin (1–3)b | S2 | H-dMrpa-A-OH | 1+/427.2088 (428.2117) |
| histrelin | S2 | pGlua-HWSY-dHBzla-LRP-NH(Et) | 2+/662.3409 (662.8423) |
| ipamorelin | S2 | Aiba-H-dNal-dFK-NH2 | 2+/356.7001 (357.2016) |
| ipamorelin (1–4)b | S2 | Aiba-H-dNal-dF-OH | 1+/585.2820 (586.2850) |
| leuprolide | S2 | pGlua-HWSYdLLRP-NH(Et) | 2+/605.3300 (605.8314) |
| leuprolide (5–9)b | S2 | YdLLRP-NH(Et) | 2+/344.7289 (345.2303) |
| LHRH | S2 | pGlua-HWSYGLRPG-NH2 | 2+/591.7938 (592.2953) |
| LHRH (2–10)b | S2 | HWSYGLRPG-NH2 | 2+/536.2778 (536.7792) |
| nafarelin | S2 | pGlua-HWSY-dNala-LRPG-NH2 | 2+/661.8251 (662.8279) |
| nafarelin (5–10)b | S2 | Y-dNala-LRPG-NH2 | 2+/401.2239 (401.7253) |
| peforelin | S2 | pGlua-HWSHDWKPG-NH2 | 2+/630.2889 (630.7903) |
| TB500 | S2 | Ac-LKKTETQ-OH | 2+/445.2531 (445.7546) |
| triptorelin | S2 | pGlua-HWSYdWLRPG-NH2 | 2+/656.3227 (656.8241) |
a
Abbreviations: Aib, aminoisobutyric acid; AzaGly, azaglycine; HBzl, benzylhistidine; Mpa, mercaptopropionic acid; Mrp, methyltryptophane; Nal, 2-naphthyl-alanine; pGlu, pyroglutamic acid; StBu, tercbutylserine.
b
Metabolite.