Table 1. Binding Free Energy (ΔG), Entropy (ΔS), and Enthalpy (ΔH) of Gemifloxacin, Paromomycin, Streptomycin, and Tobramycin with FmtA Calculated from Our Own N-Layered Integrated Molecular Orbital and Molecular Mechanics (ONIOM) Method Using B3LYP/6-311G (d,p): AMBER.

complex	ΔG (kcal/mol)	ΔH (kcal/mol)	ΔS (cal/mol/K)
FmtA–gemifloxacin	–49.52	–68.99	–65.28
FmtA–paromomycin	–50.45	–69.22	–62.94
FmtA–streptomycin	–47.59	–65.32	–59.45
FmtA–tobramycin	–45.23	–64.08	–63.23