Table 3. Thermodynamic Parameters Determined by Colorimetric Titration of Different Ligands with FmtAΔ80.
compound | enthalpy change (cal/mol) | entropy change (cal/mol/K) | free-energy change (cal/mol) | N | KD (μM) |
---|---|---|---|---|---|
gemifloxacin | 3.9 × 104 | 158 | –7.88 × 103 | 1.87 | 1.7 |
parmomycin | –1.2 × 104 | –15.6 | –7.17 × 103 | 0.868 | 8.56 |
streptomycin | 6.9 × 103 | 45.9 | –6.75 × 103 | 1.62 | 11.13 |
tobramycin | –1.0 × 106 | –3360 | –7.72 × 103 | 0.750 | 25.77 |