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. 2022 Oct 20;13:960709. doi: 10.3389/fimmu.2022.960709

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Copyright © 2022 Wu, Han, Wu, Wang, Su, Shen, Guan, Michal, Jiang, Liu and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Correlation between transcriptomic BTM clusters and metabolomic clusters; The magenta to green scale color indicates a positive to negative Pearson’s correlation coefficient, and coefficient values and the corresponding p-values were labeled on the boxes. (B(a)) Correlation between B cell surface signature (S2) module and 2,5-dihydroxybenzoate. (B(b)) Correlation between T cell activation (II) (M7.1) module and L-tryptophan. (C) Correlation between DE metabolites in cluster 1, 4 and marker genes in T cells, B cells, DCs, neutrophils and monocytes related modules; the horizontal axis represents DEGs, and the vertical axis represents DE metabolites. Top 2 significant metabolites were marked by "*".