Figure 1.

Pedigree of the family and platelet responses to therapeutic approaches. (A) Family pedigree and presence of SRC-RT resulting from Src p.E527K gain-of-function mutation. The upper left quarter burgundy shading in symbols indicates individuals with macrothrombocytopenia (MTP), the lower left quarter blue shading denotes neurological complications, the upper right quarter gray shading indicates immune defects (other than ITP) and recurrent infections, and the lower right quarter black shading indicates thrombosis. The deceased patient is indicated by a slash symbol. Patients carrying the heterozygous c.1579G>A variant in SRC are identified with GA genotype, and noncarriers with GG genotype. (B) Platelet responses to splenectomy and/or corticosteroids. The graphs show the timing of splenectomy and corticosteroid therapy and platelet count profiles of patients 3, 6, 7, and 12.