Table 3.

Individual cases of IFD

Patient	Age (y)	Sex	Lymphoma histology	Prior transplant	Product	CRS	Max grade CRS11	Tocilizumab for CRS or ICANS	Number tocilizumab doses	ICANS	Max Grade ICANS (CTCAE)	Corticosteroids for CRS or ICANS	Disease progression	D+ relapse	Alive	D+ Death	Cause of death	IFI	Organism	Site	Proven / probable	D+ diagnosis	Leukopenia on D+ diagnosis
1	65	Male	tCLL	AUTO	Axi-cel	Yes	1	Yes	1	Yes	3	Yes	Yes	11	No	17	PD	Invasive pulmonary aspergillosis	Aspergillus, ssp	Pulmonary	Probable	13	WBC: 0.17 ANC: ∼0 ALC: ∼0
2	38	Female	DLBCL	AUTO	Axi-cel	Yes	2	Yes	4	Yes	3	Yes	No	—	Yes	—	—	C albicans empyema	C. albicans	Pleural	Proven	16	WBC: 10860 ANC: 980 ALC: 9560
3	38	Male	PMBCL	AUTO	Axi-cel	Yes	1	Yes	2	Yes	3	Yes	No	—	No	18	Septic shock	C tropicalis fungemia	C. tropicalis	Blood	Proven	17	WBC: 220 ANC: 0 ALC: 200
4	64	Male	DLBCL	AUTO	Axi-cel	Yes	2	Yes	2	No	0	No	Yes	459	Yes	—	—	PJP	P. jirovecii	Pulmonary	Proven	115	WBC: 2160 ANC: 1300 ALC: 240
5	64	Male	DLBCL	AUTO	Axi-cel	Yes	1	No	0	Yes	2	Yes	No	—	Yes	—	—	PJP	P. jirovecii	Pulmonary	Probable	443	WBC: 14610 ANC: 13500 ALC: 410
6	63	Male	DLBCL	AUTO	Axi-cel	Yes	1	Yes	3	Yes	3	Yes	No	—	Yes	—	—	PJP	P. jirovecii	Pulmonary	Probable	390	WBC: 4700 ANC: 2910 ALC: 1130
7	57	Male	DLBCL	AUTO	Axi-cel	0	0	No	0	No	0	No	Yes	10	No	10	PD	Rhizopus pulmonary infection	Rhizopus ssp.	Pulmonary	Probable	7	WBC: 1450 ANC: 1090 ALC: 130
8	65	Male	tCLL	No	Axi-cel	Yes	2	Yes	4	Yes	3	Yes	Yes	30	No	72	PD	Invasive pulmonary aspergillosis	A fumigatus	Pulmonary	Probable	35	WBC: 1510 ANC: 940 ALC: 110

ALC, absolute lymphocyte count; AUTO, autologous Axi-cel, axicabtagene ciloleucel; DLBCL, diffuse large B-cell lymphoma; max, maximum; PD, progressive disease; PMBCL, primary mediastinal B-cell lymphoma; tCLL, transformed CLL; WBC, white blood cell.