Table 2.
Rates of ICH, major ICH, and fatal ICH in patients with primary brain cancer or brain metastases
| Outcome | No. of studies | No. of ICH/no. of patients | Rate | 95% CI | I 2 |
|---|---|---|---|---|---|
| Overall ICH | 30 | 445/3893 | 7.7% | 5.1-11.5 | 92.8% |
| Major ICH | 7 | 117/1287 | 6.2% | 2.8-13.0 | 91.5% |
| Fatal ICH | 11 | 13/764 | 2.9% | 1.7-4.7 | 0% |
| ICH in PBC patients | 18 | 156/2353 | 6.4% | 4.1-9.9 | 84.4% |
| ICH in MBC patients | 9 | 218/1009 | 13.0% | 6.5-24.2 | 93.7% |
| Major ICH in PBC patients | 4 | 30/793 | 3.9% | 1.3-11.6 | 87.6% |
| Major ICH in MBC patients | 3 | 87/494 | 15.4% | 9.4-24.2 | 74.6% |
| ICH in patients with VTE | 25 | 384/3313 | 7.1% | 4.4-11.5 | 93.7% |
MBC, metastatic brain cancer; PBC, primary brain cancer.