Table 3.
Rates of ICH in patients with primary brain cancer or brain metastases treated with or without anticoagulants
| Setting | No. of studies | No. of ICH/no. of patients treated | Anticoagulant therapy | No. of ICH/no. of patients not treated | No anticoagulant therapy | RR | 95% CI | P | I 2 |
|---|---|---|---|---|---|---|---|---|---|
| Overall patients | 17 | 152/1072 | 11.5% (95% CI, 7.4-17.6) |
177/1824 | 6.0% (95% CI, 3.0-11.5) |
1.81 | 1.15-2.84 | .001 | 60.3% |
| Patients with PBC | 11 | 80/659 | 12.5% (95% CI, 8.0-18.8) |
50/1346 | 4.4% (95% CI, 2.5-7.7) |
2.58 | 1.59-4.19 | <.001 | 45.5% |
| Patients with MBC | 4 | 61/265 | 14.7% (95% CI, 4.4-39.2) |
81/301 | 15.4% (95% CI, 5.3-37.2) |
0.86 | 0.45-1.65 | .287 | 0% |
| Patients treated with DOACs vs LMWH | 5 | 12/172 | 8.3% (95% CI, 4.4-15.3) |
71/278 | 11.7% (95% CI, 2.9-37.0) |
0.44 | 0.25-0.79 | .007 | 0% |
| Patients treated with LMWH vs warfarin | 4 | 15/211 | 5.9% (95% CI, 1.5-20.5) |
8/198 | 5.4% (95% CI, 1.5-17.3) |
1.45 | 0.56-3.79 | .185 | 0% |
| Overall major ICH | 4 | 33/239 | 10.4% (95% CI, 4.0-24.5) |
47/734 | 3.4% (95% CI, 0.6-17.6) |
1.93 | 0.79-4.73 | .001 | 38.7% |
| Major ICH in patients with PBC | 3 | 9/135 | 6.3% (95% CI, 1.7-20.3) |
9/545 | 1.8% (95% CI, 0.9-3.4) |
3.75 | 1.6-4.5 | .003 | 0% |
MBC, metastatic brain cancer; PBC, primary brain cancer.