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. 2022 Sep 22;6(18):5403–5414. doi: 10.1182/bloodadvances.2021006654

Figure 2.

Figure 2.

Somatically mutated genes in IEI-related lymphomas. (A) Genes affected by nonsilent, somatically occurring mutations in at least 2 IEI lymphomas or involved in DNA repair pathways are displayed as 3 groups, namely, patients with APDS (PIK3CD mutated) or APDS-like immunodeficiency (PTEN mutated), CVID, and DNA repair deficiency syndromes. Functional DLBCL oncogenes are marked with a red hash symbol. The non-IEI lymphoma data were downloaded from previous studies of DLBCL and MZL.42-44 (B) The recurrent CNVs in IEI lymphomas. (C) Significantly recurrently mutated genes in IEI DLBCL vs non-IEI DLBCLs are shown (adjusted P < .1). For the non-IEI cohort, which consisted of both HBsAg-positive and -negative patients, HBsAg+ patients were excluded. (D) The positions of the 3 BRWD3 stop-gain mutations are shown. #, previously described oncogenes for DLBCL; EBV B-lym, EBV-associated B-cell lymphoma; T-lym, T-cell lymphoma; WD, tryptophan-aspartic acid.