. 2022 Oct 17;7(43):39147–39158. doi: 10.1021/acsomega.2c05015

Table 1. Solvent Screening for the Synthesis of 8a^a.

entry	solvent	time (h)	yield^b (%)
1	CH₃CN	24	n.r.
2	IPA	24	27
3	DMF	24	n.r.
4	EtOH	24	70
5	THF	24	n.r.
6	DCM	24	n.r.
7	CHCl₃	24	n.r.
8	H₂O	24	39
9	MeOH	24	61
10	solvent-free	24	25
11^c	neat	12	46
12	EtOH:H₂O (1:1 v/v: 5 mL)	5.5	78
13	EtOH:H₂O (1:1 v/v: 10 mL)	2.5	93
14	EtOH:H₂O (1:2 v/v: 10 mL)	5	75
15	EtOH:H₂O (2:1 v/v: 10 mL)	7	69

Reaction conditions: 5 (1 equiv), 6a (1 equiv), and 7 (1 equiv) at room temperature. 5 mol % catalyst.

Yield of the isolated product.

60 °C. n.r.—no reaction

Table 1. Solvent Screening for the Synthesis of 8aa.