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. 2022 Oct 20;9:1011732. doi: 10.3389/fnut.2022.1011732

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Copyright © 2022 Corrêa, Castro, Moser, Ferreira, Quesniaux, Vinolo and Ryffel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of butyrate in ameliorating allergic asthma. Allergic asthma is associated with sensitization to aeroallergens such as air pollution, bacteria, pollen, and viruses. Exposure to the allergen induces airway epithelial injury, triggering an inflammatory response with enhanced cytokine production and, consequently, airway hyper-responsiveness, narrowing, and mucus hyperplasia. Butyrate produced in the gut reaches the lungs through the bloodstream and regulates inflammatory cells through histone deacetylase (HDAC) inhibition, thus attenuating asthmatic symptoms and pulmonary damage. All figures were created with BioRender.com.