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Chemical stability profile of compounds 1, 2, 3, and 4. (A) Analysis at pH 7.4. (B) Analyses at pH 2, showing that non-N-methylated analogs, LASSBio-1771 (1) and LASSBio-1773 (3), were unstable in pH 2. Experiments were performed in triplicate, and the average values are represented.
