Figure 8.

Microsomal profile of LASSBio-1771 (1) (10 μM). IS, internal standard (biphenyl l-4-carboxylate methyl, 10 μM). (A) Incubation at 0 min, compound 1, Rt = 10.3 min; (B) 24 h incubation at 37 °C in the presence of NADPH, no metabolite peaks were identified; (C) 24 h incubation at 37 °C in the absence of NADPH, no metabolite peaks were identified; (D) recovery rate of compound 1 at 0, 3, 8, and 24 h of incubation in the presence and absence of NADPH.