Reviewer name and names of any other individual's who aided in reviewer	Yoonjoo Choi
Do you understand and agree to our policy of having open and named reviews, and having your review included with the published manuscript. (If no, please inform the editor that you cannot review this manuscript.)	Yes
Is the language of sufficient quality?	Yes
Please add additional comments on language quality to clarify if needed	There are some minor typos. Perhaps this would not be a matter in other systems or viewer - all "fi" do not appear on my computer (Mac OS Preview), e.g. "affinity" -> "a inity", "artificial" -> "arti cial".
Is there a clear statement of need explaining what problems the software is designed to solve and who the target audience is?	Yes
Additional Comments	The purpose of this software is clearly stated and it will be very useful for researchers in relevant research fields.
Is the source code available, and has an appropriate Open Source Initiative license <a href="https://opensource.org/licenses" target="_blank">(https://opensource.org/licenses)</a> been assigned to the code?	Yes
Additional Comments
As Open Source Software are there guidelines on how to contribute, report issues or seek support on the code?	Yes
Additional Comments
Is the code executable?	Yes
Additional Comments
Is installation/deployment sufficiently outlined in the paper and documentation, and does it proceed as outlined?	Yes
Additional Comments	The author recommended running this package on Linux machines, though it is written in Python. It would be great for a non-linux user to run TEPITOPE and BasicMHC1 (for a quick epitope screen). I pip-installed it on both Ubuntu and Mac OS (just to see whether I can run TEPITOPE and BasicMHC1). The installation on Ubuntu was very easy and running fine. The Mac OS installation failed, but perhaps not the trouble of epitopepredict (brew installed Python 3.9.0).
Is the documentation provided clear and user friendly?	Yes
Additional Comments
Is there a clearly-stated list of dependencies, and is the core functionality of the software documented to a satisfactory level?	Yes
Additional Comments
Have any claims of performance been sufficiently tested and compared to other commonly-used packages?	Yes
Additional Comments	(Definitely not mandatory at all but) It would be great this package also provides a wrapper for the IEDB tools.
Are there (ideally real world) examples demonstrating use of the software?	Yes
Additional Comments
Is automated testing used or are there manual steps described so that the functionality of the software can be verified?	Yes
Additional Comments
Any Additional Overall Comments to the Author
Recommendation	Minor Revisions