Figure 2.

Overview of mouse models of PCOS. The selection of animal models is crucial and depends on the specific research question. Always use gold standard methods for phenotypic testing and finalize mice in the same estrus cycle day to avoid hormonal fluctuations affecting the phenotypic and molecular outcomes. For functional and molecular analyses, select state-of-the-art methods although this is out of the scope for this review. DHT, dihydrotestosterone; ITT, insulin tolerance test; OGTT, oral glucose tolerance test. Created with BioRender.com.