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. 2022 Nov 2;20:498. doi: 10.1186/s12967-022-03695-y

Table 1.

Specific characteristics of the seven studies included in the meta-analysis

Study Country Sample size (experiment/control) Age (years) Interventions Administration form Probiotic strain Duration Outcomes
Mahboobi et al. [5] Iran 56 (28/27) 25–65 Probiotic/Placebo Capsule Lacbotacillus casei; Lacbotacillus acidophilus; Lacbotacillus phamnosus, etc.

8

weeks

(8)
Kassaian et al. [21] Iran 85 (27/30/28) 35–75 Probiotic/Synbiotic/Placebo Powder Lactobacillus acidophilus; Bifidobacterium lactis; Bifidobacterium bifidum, etc.

24

weeks

(1)(2)(3)(4)
Naito et al. [17] Japan 98 (48/50) 20–64 Lactobacillus casei strain Shirota/Placebo Milk Lactobacillus casei strain Shirota 14–15 weeks (1)(2)(4)(5)(6)(7)(8)
Toshimitsu et al. [22] Japan 126 (62/64) 20–64 Lactobacillus plantarum OLL2712/Placebo Yogurt Lactobacillus plantarum OLL2712

12

weeks

(1)(2)(4)
Yan et al. [23] China 72 (41/31) 35–65 Probiotic/Placebo Capsule Bifidobacterium; Lactobacillus-acidophilus; Enterococcus-faecalis

2

years

(1)(4)(5)(6)(7)(8)
Oh et al. [24] Korea 37 (20/17) 19–70 Lactobacillus plantarum HAC01/Placebo Capsule Lactobacillus plantarum HAC01

8

weeks

(1)(2)(3)(4)
Stefanaki et al. [25] Greece 17 (7/10) 12–20 Probiotic/Placebo Sachet Streptococcus thermophilus; Bifidobacteria breve; Bifidobacteria longum, etc.

4

months

(1)(2)(5)(6)

(1) = FBG; (2) = HbA1c; (3) = QUICKI; (4) = HOMA-IR; (5) = TC; (6) = TG; (7) = HDL-C; (8) = LDL-C.