Fig. 2.

Association between brain Aβ deposition and self-perceived cognitive decline. Multiple regression models show that neither SCDQ nor MACQ scores were significantly associated with SUVR. Higher SCDQ and MACQ scores indicate increased subjectively perceived cognitive decline. Models were adjusted for age, sex, years of education, BMI, presence of APOE4, GDS, CDR-SB, the presence of frailty, SNSB-C Z-scores, and history of ever smoking, heavy alcohol drinking, hypertension, diabetes mellitus, cardiovascular diseases, and dyslipidemia. Abbreviations: Aβ, amyloid β; AβO, amyloid-β oligomer; APOE4, apolipoprotein E ε4 allele; BMI, body mass index; CDR-SB, Clinical Dementia Rating–Sum of Boxes; GDS, Geriatric Depression Scale; MACQ, Memory Complaint Questionnaire; SCDQ, Subjective Cognitive Decline Questionnaire; SNSB-C, Seoul Neuropsychological Screening Battery-Core; SUVR, standard uptake value ratio