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ROC curves estimating flutemetamol PET positivity. ROC curves using A plasma AβO level alone and B plasma AβO level combined with APOE4. SUVR ≥ 1.23 was regarded as flutemetamol PET (+). Abbreviations: AβO, amyloid-β oligomer; APOE4, apolipoprotein E ε4 allele; AUC, area under the curve; NPV, negative predictive value; PET, positron emission tomography; PPV, positive predictive value; ROC, receiver operative characteristic; SUVR, standard uptake value ratio
