Table 2.
Association of plasma AβO level with flutemetamol PET positivity in logistic regression analysis
Independent variable | Adjusted OR | 95% confidence interval | p-value |
---|---|---|---|
AβO (ratio) | 2.04 | 1.18–4.47 | 0.04 |
AβO (concentration [ng/mL]) | 1.58 | 1.08–2.58 | 0.04 |
In logistic regression models, the outcome variable was the flutemetamol PET positivity (SUVR cutoff ≥ 1.23), and the independent variable was plasma oligomerized Aβ level (ratio or concentration [ng/mL]). The AβO level was rescaled by multiplying 10 by the original value. Models were adjusted for age, sex, years of education, BMI, presence of APOE4, GDS, CDR-SB, the presence of frailty, SNSB-C Z-scores, and history of ever smoking, heavy alcohol drinking, hypertension, diabetes mellitus, cardiovascular diseases, and dyslipidemia
Abbreviations: Aβ, amyloid β; AβO, amyloid-β oligomer; BMI, body mass index; APOE4, apolipoprotein E ε4 allele; CDR-SB, Clinical Dementia Rating-Sum of Boxes; GDS, Geriatric Depression Scale; OR, odds ratio; PET, positron emission tomography; SCD, subjective cognitive decline; SNSB-C, Seoul Neuropsychological Screening Battery-Core; SUVR, standard uptake value ratio