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CDs delayed OA progression in vivo. A H&E staining and Safranin O and fast green staining results of different samples. B OARSI score evaluation in different samples. C The staining of COLII and MMP13 and its relative intensity in different samples. D H&E staining of heart, liver, spleen, lung, and kidney tissues to examine the toxicity of CDs. Scar bar: 100 μm *p < 0.05; **p < 0.01; ***p < 0.001
