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. 2022 Nov 3;20:469. doi: 10.1186/s12951-022-01681-6

Fig. 9.

Fig. 9

Macrophage CM and co-culture with chondrocytes. A The mRNA expression of markers involved in extracellular matrix degradation, oxidative stress, and inflammation in chondrocytes with macrophage CM incubation was determined. B Representative markers for cartilage degeneration in macrophage CM-treated chondrocytes was estimated by immunofluorescence assay. Scar bar: 20 μm. C The statistical analysis results of fluorescence intensity. D The concentration of TNF-α and IL-6 in macrophage CM-treated chondrocytes. **p < 0.01; ***p < 0.001