Table 5.
Odds ratios (95% CI) for gestational diabetes according to endocannabinoids (AEA and 2-AG) and anthropometric indices (weight, weight gain, and BMI)
| Variable | Or (CI) | Ba | *P- value |
|---|---|---|---|
| AEA (ng/ml) | |||
| Model 1 | 1.22 (1.06–1.41) | 0.20 | 0.004 |
| Model 2 | 1.54 (1.19–1.97) | 0.43 | 0.001 |
| Model 3 | 1.46 (1.11–1.91) | 0.37 | 0.006 |
| Model 4 | 1.38 (0.99–1.92) | 0.32 | 0.05 |
| 2-AG (ng/ml) | |||
| Model 1 | 1.22 (1.06–1.41) | 0.20 | 0.004 |
| Model 2 | 1.33 (1.10–1.61) | 0.28 | 0.003 |
| Model 3 | 1.23 (1.007–1.50) | 0.20 | 0.04 |
| Model 4 | 1.25 (0.94–1.65) | 0.22 | 0.11 |
| Weight (kg) | |||
| Model 1 | 1.14 (1.04–1.26) | 0.13 | 0.006 |
| Model 2 | 1.11 (0.99–1.23) | 0.10 | 0.05 |
| Model 3 | 1.05 (0.92–1.20) | 0.05 | 0.40 |
| Model 4 | 1.003 (0.85–1.17) | 0.003 | 0.97 |
| Weight gain (kg) | |||
| Model 1 | 1.93 (1.35- 2.74) | 0.65 | < 0.001 |
| Model 2 | 2.07 (1.28–3.33) | 0.72 | 0.003 |
| Model 3 | 1.87 (1.12- 3.12) | 0.62 | 0.01 |
| Model 4 | 3.24 (1.55–6.80) | 1.17 | 0.002 |
| BMI (kg/m2) | |||
| Model 1 | 2.06 (1.38- 3.06) | 0.72 | < 0.001 |
| Model 2 | 1.59 (1.04–2.43) | 0.46 | 0.02 |
| Model 3 | 1.54 (0.77- 3.05) | 0.43 | 0.21 |
| Model 4 | 2.18 (0.88- 5.42) | 0.78 | 0.09 |
Abbreviation: AEA Anandamide, 2-AG 2-Arachidonoylglycerol, BMI Body mass index
a B coefficient; regression slope
* P < 0.05 statistically significant by Multivariable logistic regression. Model 1: unadjusted, model 2: adjusted for energy, carbohydrate, protein, and fat, model 3: adjusted for energy, carbohydrate, protein, and fat, weight gain, and BMI, model 4: adjusted for energy, carbohydrate, protein, and fat, weight gain, BMI, age, education, job, level of physical activity, sex of infant, family history of type 2 diabetes and gestational diabetes, number of pregnancies and weeks of pregnancy