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. Author manuscript; available in PMC: 2022 Nov 3.
Published in final edited form as: Ann Surg. 2015 Oct;262(4):563–569. doi: 10.1097/SLA.0000000000001439

TABLE 1.

Estimated number of subjects required for detection* of various effect sizes (β#) according to marker minor allele frequency.

Regression coefficient β#
0.10 0.20 0.30 0.40 0.50
Minor allele frequency 0.10 11386 2833 1249 694 438
0.20 6397 1585 694 382 238
0.30 4869 1204 525 287 177
0.40 4258 1051 457 249 152
0.50 4087 1008 438 238 145
*

With 80% power and a type-I error rate of 2×10−7, assuming an additive model of inheritance.

#

Linear regression coefficient corresponding to average difference in Vancouver Scar Scale height score (range: 0–3) associated with each additional rare allele.