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. 2022 Nov 3;208:105458. doi: 10.1016/j.antiviral.2022.105458

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© 2022 The Authors

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Fig. 2 — Biochemical inhibition assays. (A) SARS-CoV-2 M^pro with AG7404. (B) SARS-CoV-2 M^pro with rupintrivir. (C) SARS-CoV-1 M^pro with AG7404. (D) SARS-CoV-1 M^pro with rupintrivir. The inhibition of M^pro activity was measured by FRET and the dose-response curves for IC₅₀ values were determined by a non-linear regression model (four parameters). Triplicate experiments were performed for each data point n = 2, and the value is presented as mean ± standard deviation (SD).