Table 2.
Cell-based inhibition assays with A549-ACE2 cell lines and SARS-CoV-2. Effective concentrations 50 and 90 (EC50 and EC90) and cytotoxic concentration 50 (CC50) are expressed in μM. Selectivity index 50 (SI50) was calculated as the ratio between the CC50 and the EC50. Remdesivir was used as a control.
| A549-ACE2 | ||||
|---|---|---|---|---|
| EC50 [95% C.I.] | EC90 [95% C.I.] | CC50 | SI50 | |
| AG7404 | 6.80 [3.20–13.51] | 90.90 [38.50–436.30] | 250 | 36.8 |
| Rupintrivir | 0.57 [0.33–0.87] | 8.46 [5.46–15.60] | >250 | >438.6 |
| Remdesivir | 0.033 [0.018–0.055] | 0.145 [0.082–0.432] | >250 | >7575.7 |