Table 3.
Associations of Endometrial Cancer Risk Factors with Histologic Outcomes in all Women (n=1,159)*
| Polyps (n=158) | p-value | DPEM (n=109) | p-value | Hyperplasia without atypia (n=30) | p-value | Atypical Hyperplasia (n=20) | p-value | Endometrial Cancer (n=49) | p-value | |
|---|---|---|---|---|---|---|---|---|---|---|
| Age (per 1 year increase) | 1.06 (1.0–1.1) | <0.0001 | 0.95 (0.9–1.0) | 0.006 | 1.03 (1.0–1.1) | 0.253 | 1.07 (1.0–1.1) | 0.045 | 1.14 (1.1–1.2) | <0.0001 |
| BMI (per 5kg/m2 increase) | 1.17 (1.0–1.3) | 0.011 | 1.12 (1.0–1.3) | 0.107 | 1.10 (0.9–1.4) | 0.446 | 2.00 (1.5–2.6) | <0.0001 | 1.39 (1.1–1.7) | 0.001 |
| HRT Use | ||||||||||
| Never (n=782) | Ref | Ref | Ref | Ref | Ref | Ref | ||||
| Ever (n=377) | 0.81 (0.5–1.2) | 0.320 | 0.75 (0.5–1.3) | 0.276 | 1.45 (0.6–3.3) | 0.369 | 1.00 (0.3–3.1) | 0.987 | 0.42 (0.2–0.9) | 0.022 |
| Past Oral Contraception Use | ||||||||||
| No (n=308) | Ref | Ref | Ref | Ref | Ref | Ref | ||||
| Yes (n=807) | 0.94 (0.6–1.4) | 0.773 | 1.30 (0.8–2.2) | 0.312 | 1.01 (0.4–2.4) | 0.980 | 0.88 (0.3–5.5) | 0.819 | 0.82 (0.4–1.6) | 0.573 |
| Parity | ||||||||||
| Nulliparous (n=192) | Ref | Ref | Ref | Ref | Ref | Ref | ||||
| Parous (n=966) | 0.58 (0.4–0.9) | 0.014 | 1.13 (0.6–2.0) | 0.674 | 0.87 (0.3–2.4) | 0.786 | 0.86 (0.3–2.9) | 0.806 | 0.60 (0.3–1.3) | 0.209 |
| Type II Diabetes | ||||||||||
| No (n=1,082) | Ref | Ref | Ref | Ref | Ref | Ref | ||||
| Yes (n=77) | 1.14 (0.6–2.3) | 0.713 | 0.88 (0.3–2.2) | 0.787 | 2.09 (0.6–7.0) | 0.235 | 1.63 (0.5–5.9) | 0.457 | 2.11 (0.9–5.2) | 0.107 |
| Hypertension | ||||||||||
| No (n=881) | Ref | Ref | Ref | Ref | Ref | Ref | ||||
| Yes (n=278) | 0.79 (0.5–1.2) | 0.303 | 1.18 (0.7–2.0) | 0.529 | 1.55 (0.6–3.7) | 0.328 | 1.59 (0.5–4.6) | 0.394 | 0.94 (0.5–1.9) | 0.870 |
| Smoking Status | ||||||||||
| Never (n=796) | Ref | Ref | Ref | Ref | Ref | Ref | ||||
| Ever (n=362) | 1.27 (0.9–1.8) | 0.196 | 1.12 (0.7–1.7) | 0.613 | 0.63 (0.3–1.5) | 0.301 | 0.57 (0.2–1.7) | 0.311 | 0.43 (0.2–0.9) | 0.030 |
| Family History of EC | ||||||||||
| No (n=1,057) | Ref | Ref | Ref | Ref | Ref | Ref | ||||
| Yes (n=102) | 0.70 (0.4–1.3) | 0.287 | 0.74 (0.3–1.6) | 0.449 | -- | -- | -- | -- | 0.71 (0.2–2.2) | 0.549 |
*
The reference group includes normal or other benign histology or no indication for biopsy, women with inadequate biopsy results are excluded (n=46)
Note: Two dashes (--) indicate the odds ratio, confidence intervals, and corresponding p-value could not be estimated from the model.
Abbreviations: DPEM, Disordered proliferative endometrium; BMI, body mass index; HRT; hormone replacement therapy; EC, endometrial cancer