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. 2022 Jul 20;27(11):e856–e869. doi: 10.1093/oncolo/oyac136

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — PDO studies. (1) HE staining of the patients tumor tissue; (2) HE staining of the patient-derived gastric cancer organoid (PDO); (3) the direct efficacy of anlotinib on the PDOs; (4) viability assay of the different treatment tumor cells from the PDOs cultivated for 7 days; (5) STRING analysis to study the potential mechanism; (6) western-blot analysis of the expression of STAT1 and STAT3 after anlotinib treatment.

Figure 4. — PDO studies. (1) HE staining of the patients tumor tissue; (2) HE staining of the patient-derived gastric cancer organoid (PDO); (3) the direct efficacy of anlotinib on the PDOs; (4) viability assay of the different treatment tumor cells from the PDOs cultivated for 7 days; (5) STRING analysis to study the potential mechanism; (6) western-blot analysis of the expression of STAT1 and STAT3 after anlotinib treatment.