Table 3.

Reasons for dose changes, dose schedule modification, and discontinuation in the all-comers cohort^a

	Dose change (n = 56)	Dose schedule modification (n = 101)	Discontinuation (n = 89)
Total
No. of events	92	236	89
Toxic effect of therapy
No. of patients (%)	21 (37.5)	79 (78.2)	41 (46.1)
No. of events	27	173	41
Disease-related symptoms not due to therapy
No. of patients (%)		9 (8.9)	9 (10.1)
No. of events		9	9
Drug–drug interaction
No. of patients (%)	14 (25.0)	4 (4.0)
No. of events	18	4
Progression
No. of patients (%)		<4 (<4.0)	11 (12.4)
No. of events		<4	11
No evidence of disease
No. of patients (%)	<4 (<7.1)	5 (5.0)	<4 (<4.5)
No. of events	<4	6	<4
Other/unknown
No. of patients (%)	35 (62.5)	40 (39.6)	27 (30.3)
No. of events	44	49	27

Reasons were available for 163/169 patients in the all-comers cohort. More than 1 episode and/or more than 1 reason could have been recorded per patient, so the percentages sum to >100%.

Abbreviations: No., number.