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. 2021 Nov 10;12:6485. doi: 10.1038/s41467-021-26417-2

Fig. 7. Image-guided surgery for small, peritoneal-disseminated metastatic Hela tumors.

Fig. 7

a Representative process of folic-AIEgen guided dissection of tiny tumors in Hela-Luc xenograft-bearing nude mice (n = 3). At 24 h after intraperitoneal injection of folic-AIEgen (100 µL, 40 µg/mL), the intestinal tract of mice was carefully pulled out and the peritoneal Hela microtumors were localized and resected under UV light. b Tumor co-localization (top) by the bioluminescence signals of Hela-Luc, fluorescence of folic-AIEgen. Image-guide tumor resection (middle) via the fluorescence of folic-AIEgen under 365 nm UV light (inner: the excised tumors). Bioluminescence imaging was performed on the mice again to confirm no residual lesions. H&E staining of the excised tumors (bottom). Scale bars = 1 mm. The experiment was repeated at least three times.