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. 2022 Oct;8(6):a006222. doi: 10.1101/mcs.a006222

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© 2022 Jain et al.; Published by Cold Spring Harbor Laboratory Press

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Figure 2. — Activated ROS1 kinase in NOTCH1–ROS1 drives downstream signaling via MAPK, PI3K/Mtor, and JAK–STAT pathways. Western blot analysis of (A) stable NIH3T3 and (B) Ba/F3 cell lines showing phosphorylated (p-) and total (t-) protein levels of MAPK, PI3K/Mtor, and JAK–STAT pathways. Western blot analysis to show activation of ROS1 kinase in (C) stable NIH3T3 and (D) Ba/F3 cell lines showing phosphorylated (p-) and total (t-) protein levels. High exposure tROS1 blot is included in Supplemental Figure 1a to show ROS1 levels in ROS1 NIH3T3 cell model.