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. 2022 Oct;8(6):a006169. doi: 10.1101/mcs.a006169

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© 2022 Mark et al.; Published by Cold Spring Harbor Laboratory Press

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Figure 5. — Mouse phenotypes for Lrp1 alterations. (A) Embryo imaging of wild-type or Lrp1 homozygous knockout, with blue representing the LacZ replacement of Lrp1. Data is from the International Mouse Phenotyping Consortium (IMPC; www.mousephenotype.org/data/genes/MGI:96828). (B,C) Heterozygous Lrp1 knockout causing significant differences in male and female heart weight (B) and lens morphology (C). (D) All phenotypes observed within the Mouse Genome Informatics (MGI) database (Supplemental Table S1) fit within the summary terms for the modified mouse strains. (E) Skeleton images of Col2a1 conditional Lrp1-knockout with zoomed images of wild type (red) and homozygous (blue) animals.