Fig. 7.

Heroin reacquisition training and punished heroin taking test for male and female rats in the high-responder/low-responder model. (a-c) Mean + SEM for infusions earned across three heroin self-administration reacquisition training sessions. High-responder/low-responder rats decreased infusions earned across training when (a) sexes were analyzed together (p<0.0001) as well as separately (b, Males: p<0.0001; c, Females: p=0.003). However, HR and LR rats did not differ from one another in any analyses suggesting the novelty-induced locomotor trait does not predict heroin reacquisition following a prolonged period of abstinence. During the punished heroin taking test, there was a 50% chance of foot shock delivery (0.40 mA, 0.5 seconds) with every infusion earned. Data represented as individual data point according to assigned phenotype. The black bar within the violin plot indicates the median value of the data set. HR and LR rats did not differ in heroin taking in the presence of the aversive foot shock delivery when sexes were analyzed together (d, p=0.67) and separately (e, Males: p=0.11; f, Females: p=0.82). *p<0.05 (Males, n= 16 (8 in each phenotype); Females, n= 14 (HR, n=5; LR, n=9))