Fig. 1.

Illustration presents contemporary guideline-directed medical therapies (GDMTs) for A) heart failure with reduced ejection fraction (HFrEF) and B) heart failure with preserved ejection fraction (HFpEF).
ARNI, angiotensin receptor neprilysin inhibitor; MRA, mineralocorticoid receptor antagonist; SGLT2i, sodium-glucose cotransporter 2 inhibitor